The Jupiter Hospital in Pune is a 350-bed multi-speciality hospital. This paper focuses on the Heating, Ventilating and Air Conditioning (HVAC) system performance of Jupiter Hospital. The Jupiter Hospital was designed as an energy efficient building in order to harness the potential to save energy by incorporating energy efficiency measures in the HVAC systems. The measures in this case include building envelope measures to reduce cooling load, optimum size of the chillier with good part load performance, and other technologies such as recovery through enthalpy wheel for fresh air and the innovative use of condensers.